Fig 3B from the following paper\r\nLogical modelling of Drosophila signalling pathways. Mbodj A, Junion G, Brun C, Furlong EE, Thieffry D. Mol Biosyst. 2013 Sep;9(9):2248-58. doi:10.1039/c3mb70187e Helikar Tomas thelika@unmc.edu University of Nebraska - Lincoln 2015-01-21T16:27:54Z 2016-01-22T07:08:46Z

BNL Fibroblast Growth Factor (Branchless)<div>UniProt ID:&nbsp;<a href="http://www.uniprot.org/uniprot/Q86NQ2" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">Q86NQ2</a></div><div>Gene Name: bnl</div><div>Gene ID:&nbsp;<span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">42356</span></div>

 2015-12-19T22:59:18Z

PYR (Pyramus) a signaling molecule<div>Gene Name: pyr</div><div>Gene ID:&nbsp;<span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">36255</span></div>

 2015-12-19T22:59:18Z

<font face="Arial, Verdana"><span style="font-size: 10pt;">RPS6KA4 = ribosomal protein S6 kinase, 90kDa, polypeptide 4&nbsp;</span></font><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;">UniProt ID:&nbsp;<a href="http://www.uniprot.org/uniprot/A0PJF8" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">A0PJF8</a></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;">Gene Name:&nbsp;<a href="http://www.ncbi.nlm.nih.gov/gene/56613" ref="ordinalpos=1&amp;ncbi_uid=56613&amp;link_uid=56613" style="color: rgb(100, 42, 143); font-family: arial, helvetica, clean, sans-serif; font-size: 13px; line-height: 17.9998016357422px; white-space: nowrap; background-color: rgb(213, 222, 227);"><span class="highlight">Rps6ka4</span></a></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;">Gene ID:&nbsp;<span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">56613</span></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><br/></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;">RPS6KA5 = ribosomal protein S6 kinase, 90kDa, polypeptide 5</div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><div style="font-size: 13.3333330154419px;">UniProt ID:&nbsp;<a href="http://www.uniprot.org/uniprot/O75582" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">O75582</a></div><div style="font-size: 13.3333330154419px;">Gene Name:&nbsp;<a href="http://www.ncbi.nlm.nih.gov/gene/9252" ref="ordinalpos=1&amp;ncbi_uid=9252&amp;link_uid=9252" style="color: rgb(100, 42, 143); font-family: arial, helvetica, clean, sans-serif; font-size: 13px; line-height: 17.9998016357422px; white-space: nowrap; background-color: rgb(213, 222, 227);"><span class="highlight">RPS6KA5</span></a></div><div style="font-size: 13.3333330154419px;">Gene ID:&nbsp;<span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">9252</span></div></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);"><br/></span></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);"><br/></span></div><div>Represented the Moleskin gene&nbsp;encodes Drosophila Importin-7 (DIM-7<span style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;">)</span></div>

 2015-12-19T22:59:18Z

Protein Kinase\r\nSuppressor of RAS<div>UniProt ID:&nbsp;<a href="http://www.uniprot.org/uniprot/Q24171" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(222, 239, 245);">Q24171</a></div><div>Gene Name: ksr</div><div>Gene ID:&nbsp;<span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(255, 255, 255);">40660</span></div>

 2015-12-19T22:59:18Z

Sprouty Protein<div>UniProt ID:&nbsp;<a href="http://www.uniprot.org/uniprot/O44783" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">O44783</a></div><div>Gene Name: sty</div><div>Gene ID:&nbsp;<span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">38424</span></div>

 2015-12-19T22:59:18Z

Tyrosine-protein phosphatase corkscrew&nbsp;(CSW)<div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;">UniProt ID:&nbsp;<a href="http://www.uniprot.org/uniprot/P29349" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">P29349</a></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;">Gene Name: csw</div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;">Gene ID:&nbsp;<span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">45278</span><span style="font-size: 10pt;">&nbsp;</span></div>

 2015-12-19T22:59:18Z

Thisbe signaling molecule<div>UniProt ID:&nbsp;<a href="http://www.uniprot.org/uniprot/Q6Q7I9" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">Q6Q7I9</a></div><div>Gene Name: ths<br/>Gene ID:&nbsp;<span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">36258</span></div>

 2015-12-19T22:59:18Z

Src oncogene<div>Gene Name: Src42A</div><div>Gene ID:&nbsp;<span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">35524</span></div>

 2015-12-19T22:59:18Z

Connector Enhancer of KSR (CNK)<div>UniProt ID:&nbsp;<a href="http://www.uniprot.org/uniprot/Q7KNQ9" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(222, 239, 245);">Q7KNQ9</a></div><div>Gene Name: cnk</div><div>Gene ID:&nbsp;<span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">36952</span></div>

 2015-12-19T22:59:18Z

<font face="Arial, Verdana"><span style="font-size: 10pt;">RL (Rolled/MAPK) m</span></font>itogen-activated protein kinase ERK-A<div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;">UniProt ID:&nbsp;<a href="http://www.uniprot.org/uniprot/P40417" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">P40417</a></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;">Gene Name: rl</div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;">Gene ID:&nbsp;<span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">3354888</span></div>

 2015-12-19T22:59:18Z

Downstream of RAF1 (DSOR1)<div>UniProt ID:&nbsp;<a href="http://www.uniprot.org/uniprot/X2JAZ3" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">X2JAZ3</a><br/>Gene Name: Dsor1</div><div>Gene ID:&nbsp;<span style="font-family: arial, helvetica, clean, sans-serif; font-size: 13px; line-height: 17.9998016357422px; background-color: rgb(255, 255, 255);">31872</span></div>

 2015-12-19T22:59:18Z

<span style="font: 10pt/normal Arial, Verdana;">Raspberry</span>&nbsp;Ras-like protein 2<font face="Arial, Verdana"><span style="font-size: 10pt;">&nbsp;(RAS)</span></font><div style="font: 10pt/normal Arial, Verdana;">UniProt ID:&nbsp;<a style="color: rgb(64, 148, 180); line-height: 20.08px; font-family: Verdana, Arial, sans-serif; font-size: 13.05px; text-decoration: none; border-bottom-width: 0px; cursor: pointer; background-color: rgb(255, 255, 255);" href="http://www.uniprot.org/uniprot/P04388">P04388</a></div><div style="font: 10pt/normal Arial, Verdana;">Gene Name: ras</div><div style="font: 10pt/normal Arial, Verdana;">Gene ID:&nbsp;<span style="color: rgb(87, 87, 87); line-height: 16.19px; font-family: arial, helvetica, clean, sans-serif; font-size: 11.69px; background-color: rgb(213, 222, 227);">43873</span></div><div style="font: 10pt/normal Arial, Verdana;"><span style="color: rgb(87, 87, 87); line-height: 16.19px; font-family: arial, helvetica, clean, sans-serif; font-size: 11.69px; background-color: rgb(213, 222, 227);"></span>&nbsp;</div><div style="font: 10pt/normal Arial, Verdana;"><span style="color: rgb(87, 87, 87); line-height: 16.19px; font-family: arial, helvetica, clean, sans-serif; font-size: 11.69px; background-color: rgb(213, 222, 227);"></span>&nbsp;</div><div style="font: 10pt/normal Arial, Verdana;"><span style="color: rgb(87, 87, 87); line-height: 16.19px; font-family: arial, helvetica, clean, sans-serif; font-size: 11.69px; background-color: rgb(213, 222, 227);"><table style="width: 723pt; border-collapse: collapse;" border="0" cellSpacing="0" cellPadding="0" width="964">\r\n <colgroup><col style="width: 723pt; mso-width-source: userset; mso-width-alt: 30848;" width="964">\r\n <tbody><tr style="height: 15pt;" height="20">\r\n\r\n <td style="border: 0px black; width: 723pt; height: 15pt; background-color: transparent;" class="xl65" height="20" width="964"><p><font color="#000000" size="3" face="Calibri"><font color="#575757" face="Arial">In [1]:</font></font></p><p><font color="#000000" size="3" face="Calibri">rat\r\n sarcoma viral oncogene homolog</font></p><p><font color="#000000" size="3" face="Calibri">Protein family</font><font color="#000000" size="3" face="Calibri">&nbsp;</font></p></td>\r\n\r\n </tr>\r\n</tbody></table></span></div>

 2015-12-19T22:59:18Z

Downstream of receptor kinase (DRK)<div>UniProt ID:&nbsp;<a href="http://www.uniprot.org/uniprot/Q08012" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">Q08012</a></div><div>Gene Name: drk</div><div>Gene ID:&nbsp;<span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">36497</span></div>

 2015-12-19T22:59:18Z

SOS1 = son of sevenless homolog 1 (Drosophila)&nbsp;<div>UniProt ID:&nbsp;<a href="http://www.uniprot.org/uniprot/Q07889" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">Q07889</a></div><div>Gene Name: SOS1</div><div>Gene ID:&nbsp;<span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">6654</span><br/><div><br/></div><div>SOS2 = son of sevenless homolog 2 (Drosophila)</div></div><div><div style="font-size: 13.3333330154419px;">UniProt ID:&nbsp;<a href="http://www.uniprot.org/uniprot/Q07890" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">Q07890</a></div><div style="font-size: 13.3333330154419px;">Gene Name: SOS2</div><div style="font-size: 13.3333330154419px;">Gene ID:&nbsp;<span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">6655</span></div></div>

 2015-12-19T22:59:18Z

Pointed (PNT)<div>UniProt ID:&nbsp;<a href="http://www.uniprot.org/uniprot/B4HFD9" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(222, 239, 245);">B4HFD9</a></div><div><span style="font-size: 10pt;">Gene Name: pnt</span></div><div>Gene ID:&nbsp;<span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">42757</span></div>

 2015-12-19T22:59:18Z

GTPase-activating protein 1 (GAP1) [fruit fly]<div>UniProt ID:&nbsp;<a href="http://www.uniprot.org/uniprot/P48423" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">P48423</a></div><div>Gene Name: gap1</div><div>Gene ID:&nbsp;<span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">2540440</span></div>

 2015-12-19T22:59:18Z

<font face="Arial, Verdana"><span style="font-size: 10pt;">PLCG1 = phospholipase C, gamma 1&nbsp;</span></font><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;">UniProt ID:&nbsp;<a href="http://www.uniprot.org/uniprot/P19174" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">P19174</a></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;">Gene Name: PLCG1</div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;">Gene ID:&nbsp;<span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">5335</span></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><br/></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;">PLCG2 = phospholipase C, gamma 2 (phosphatidylinositol-specific)&nbsp;</div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><div style="font-size: 13.3333330154419px;">UniProt ID:&nbsp;<a href="http://www.uniprot.org/uniprot/P16885" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">P16885</a></div><div style="font-size: 13.3333330154419px;">Gene Name: PLCG2</div><div style="font-size: 13.3333330154419px;">Gene ID:&nbsp;<span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">5336</span></div></div><div style="font-family: Arial, Verdana; font-size: 13.3333330154419px; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);"><br/></span></div><div>Enzyme&nbsp;<span style="font-family: arial, helvetica, clean, sans-serif; font-size: 13px; line-height: 17.9998016357422px; background-color: rgb(213, 222, 227);">phospholipase C gamm</span>&nbsp;(PLCG) (fruit fly)</div><div><br/></div><div><br/></div>

 2015-12-19T22:59:18Z

<font face="Arial, Verdana" style="font-style: normal; font-variant: normal; font-weight: normal;"><span style="font-size: 10pt;">RAF1 = v-raf-1 murine leukemia viral oncogene homolog 1&nbsp;</span></font><div style="font-style: normal; font-variant: normal; font-weight: normal; font-family: Arial, Verdana; font-size: 10pt; line-height: normal;">UniProt ID:&nbsp;<a href="http://www.uniprot.org/uniprot/P04049" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">P04049</a></div><div style="font-style: normal; font-variant: normal; font-weight: normal; font-family: Arial, Verdana; font-size: 10pt; line-height: normal;">Gene Name: RAF1</div><div style="font-style: normal; font-variant: normal; font-weight: normal; font-family: Arial, Verdana; font-size: 10pt; line-height: normal;">Gene ID:&nbsp;<span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">5894</span><br/><div><br/></div><div>BRAF = v-raf murine sarcoma viral oncogene homolog B1</div><div><div style="font-size: 13.3333330154419px;">UniProt ID:&nbsp;<a href="http://www.uniprot.org/uniprot/P15056" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">P15056</a></div><div style="font-size: 13.3333330154419px;">Gene Name: BRAF</div><div style="font-size: 13.3333330154419px;">Gene ID:&nbsp;<span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">673</span></div></div><div><br/></div><div>ARAF = v-raf murine sarcoma 3611 viral oncogene homolog</div></div><div style="font-style: normal; font-variant: normal; font-weight: normal; font-family: Arial, Verdana; font-size: 10pt; line-height: normal;"><div style="font-size: 13.3333330154419px;">UniProt ID:&nbsp;<a href="http://www.uniprot.org/uniprot/P10398" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">P10398</a></div><div style="font-size: 13.3333330154419px;">Gene Name: ARAF</div><div style="font-size: 13.3333330154419px;">Gene ID:&nbsp;<span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">369</span></div></div><div style="font-style: normal; font-variant: normal; font-weight: normal; font-family: Arial, Verdana; font-size: 13.3333330154419px; line-height: normal;"><span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);"><br/></span></div><div>Pole hole Raf [fruit fly]</div><div>UniProt ID:&nbsp;<a href="http://www.uniprot.org/uniprot/P11346" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">P11346</a></div><div>Gene Name: phl</div><div>Gene ID:&nbsp;<span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">31221</span></div>

 2015-12-19T22:59:18Z

Target nodes from the paper [1]

 2015-12-19T22:59:18Z

(Breathless) BTL&nbsp;<div>UniProt ID:&nbsp;<a href="http://www.uniprot.org/uniprot/B3M3I2" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(222, 239, 245);">B3M3I2</a><span style="font-size: 10pt;">&nbsp;</span></div><div>Gene Name: btl</div><div>Gene ID: <span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">39564</span></div>

 2015-12-19T22:59:18Z

<div>The intracellular protein Stumps (also called Heartbroken or\r\nStumps)</div>UniProt ID:&nbsp;<a href="http://www.uniprot.org/uniprot/Q1WWH6" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">Q1WWH6</a><div>Gene Name: stumps</div><div>Gene ID:&nbsp;<span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">41770</span></div>

 2015-12-19T22:59:18Z

<div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;">transcriptional Co-repressor Anterior Open</div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;">UniProt ID:&nbsp;<a href="http://www.uniprot.org/uniprot/B4LTU0" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(222, 239, 245);">B4LTU0</a></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;">Gene Name: aop</div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;">Gene ID:&nbsp;<span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">33392</span></div>

 2015-12-19T22:59:18Z

Heartless, Drosophila FGF receptor)<div>UniProt ID:&nbsp;<a href="http://www.uniprot.org/uniprot/Q07407" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13.0571994781494px; line-height: 20.081974029541px; background-color: rgb(222, 239, 245);">Q07407</a></div><div>Gene Name: htl</div><div>Gene ID:&nbsp;<span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 11.6999998092651px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">42160</span></div>

 2015-12-19T22:59:18Z

Dsor1 and MSK positively regulates Rl [1, 2, 3].

MSK is tyrosine phosphorylated in response to growth factor\r\nstimulation of FGF signalling and physically binds\r\nDrosophila RL.\r\nMSK is a General RL Nuclear Import Factor. [1, 2]&nbsp;

<span style="font-weight: normal;">Activated RAS then promotes the activation of RAF (Pole hole), DSOR1, and eventually that of\r\nRL (Rolled)</span><strong>&nbsp;[1]</strong><div>After phosphorylation by DSOR1 and translocation in the\r\nnucleus, RL phosphorylates PNT. [1, 3]</div>

 S_2 1 S_8 1

Raf activates Dsor1 [1, 2].

Downstream of RAF1 (DSOR1) is the kinase which\r\nphosphorylates RL , which can then enters in the nucleus. [1, 2]&nbsp;

 S_12 1

Sos positively regulates ras [1, 2, 3]. Gap can positively and negatively regulates ras [1, 5]. Sos<span style="font-size: 13.3333330154419px;">&nbsp;can positively and negatively regulates ras [1, 4].</span>

SOS (Son of sevenless) is a guanine nucleotide-releasing\r\nfactor that activates RAS [1, 2, 3]

STY (Sprouty) inhibits receptor tyrosine kinase (RTK)\r\nsignalling by intercepting essential elements of the RAS/RAF\r\ncascade through diverse mechanisms [1, 4]

GTPase-activating protein 1 (GAP) protein stimulates the\r\nhydrolysis of GTP bound to RAS, thereby converting RAS\r\ninto the GDP-bound, inactive state [1, 5]&nbsp;

 S_10 1 S_7 1 S_14 1 S_14 1 S_14 1 S_10 1 S_10 1 S_7 1 S_7 1

<span style="font-size: 13.3333330154419px;">Csw positively regulates Drk [1]. Stumps</span><span style="font-size: 13.3333330154419px;">&nbsp;positively regulates Drk [1, 2]</span>

Stumps could bind SH2 domains of proteins such as DRK [1, 2]

Csw positively regulates Drk [1]

 S_18 1 S_15 1

Drk activates SOS [1]

DRK\r\nrecruits the guanine nucleotide exchange factor SOS [1, 2, 3]

 S_5 1

Rl activates Pnt [1, 2]

After phosphorylation by DSOR1 and translocation in the\r\nnucleus, RL phosphorylates PNT. [1, 2].

 S_1 1

PLCg activates gap [1]

<span style="font-size: 13.3333330154419px;">PLCg activates gap [1]</span>

 S_11 1

Drk activates PLCG [1]

<span style="font-size: 13.3333330154419px;">Drk activates PLCG [1]</span>

 S_5 1

Ras activates raf in conjunction with Cnk, Ksr, and Src42 [1, 2, 3,4 ,5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16].

"CNK (Connector Enhancer of KSR) is required upstream of\r\nRAF" [1, 11]&nbsp;<div>"CNK directly associates with the kinase domain of RAF via a\r\nshort amino-acid sequence, called the RAF-interacting motif" [12, 13]</div>

"This initiates a kinase cascade in which RAF phosphorylates\r\nDSOR1 in the presence of KSR" [1, 2]<div>"KSR (Kinase suppressor of RAS) facilitates the\r\nphosphorylation of DSOR1 and RL by RAF" [3, 4, 5, 6, 7, 8, 9, 10]</div>

"GTP-RAS activates the kinase RAF." [1, 2]&nbsp;

"SRC oncogene at 42A (SRC42) interacts with CNK and\r\ncontributes to RAF activation" [1, 14, 15, 16]

 S_4 1 S_22 1 S_13 1 S_21 1

Pnt activates FGF targets [1, 2, 3, 4, 5, 6, 7]. Aop inhibits Targets [1, 8].

AOP (Anterior open) inhibits RTK targets genes. [1, 8]&nbsp;

Drosophila FGF target genes are activated by phosphorylated\r\nPNTP2 [1, 2, 3, 4, 5, 6, 7]

 S_9 1 S_20 1

Bnl activates Btl [1, 2]

BNL binding activates drosophila BTL (Breathless) FGF\r\nreceptor and thereby controls the movement (branching) of\r\nthe trachea [1, 2]

 S_3 1

<span style="font-size: 13.3333330154419px;">Htl activates Stumps [1]. B</span><span style="font-size: 13.3333330154419px;">tl activates Stumps [1].</span>

Htl activates Stumps [1].

<span style="font-size: 13.3333330154419px;">Btl activates Stumps [1].</span>

 S_23 1 S_17 1

Rl inhibits Aop [1, 2].

<span style="font-size: 13.3333330154419px;">Rl inhibits Aop [1, 2].</span>

 S_1 1

Ths positively regulates Htl [1]. Pyr<span style="font-size: 13.3333330154419px;">&nbsp;positively regulates Htl [1].</span>

<span style="font-size: 13.3333330154419px;">Ths positively regulates Htl [1]</span>

<span style="font-size: 13.3333330154419px;">Pyr</span><span style="font-size: 13.3333330154419px;">&nbsp;positively regulates Htl [1].</span>

 S_6 1 S_19 1